determination of acid-neutralizing capacity for over-the-counter antacids as per USP

The same way too little stomach acid causes indigestion, too much stomach acid has the same effect. Chamomile tea is known to help induce sleep and calm anxiety. This herb can also ease gut discomfort and relieve indigestion by reducing stomach acid in the gastrointestinal tract. Chamomile also acts as an anti-inflammatory to stop pain.

The present study evaluates and compares the antacid effect of broccoli, kale, radish, cucumber, lemon juice, cold milk and curd in an artificial stomach model. Aluminum Hydroxide [Al(OH)3] – Compared to magnesium hydroxide, aluminum hydroxide is a weak, slow-acting antacid, and its acid-neutralizing effect varies among commercial products. Magnesium hydroxide is not absorbed by the intestine.

The resulting solution will be acidic because the tablet did not provide enough moles of base to completely neutralize the acid. The solution will be titrated with base of known concentration to determine the amount of acid not neutralized by the tablet.

The least cost-effective antacid neutralizes the smallest volume of acid for the highest price. The sample data indicates that Phillips’ MOM neutralizes the smallest volume of acid for the highest price. In fact, it only neutralizes 2.4 mL of acid per penny spent.


Add the powdered antacid to the beaker and stir. Observe for several minutes. This represents the antacid tablet being introduced into the acid stomach. Record all observations in Data Table 1. Do not ingest any of the antacid drug samples during this laboratory.

It was demonstrated that it is possible to modify kaolin with sodium carbonate solution in different concentrations. These modified solids can be used as effective antacid drugs. The effectiveness of these synthesized medicaments depends on the concentration of sodium carbonate used; a major concentration in these solutions generates an increase in the effectiveness of the drugs. The neutralization test shows that lower doses used, such as, 250 mg can be used to reach the normal pH of the stomach.

Gastroesophageal Reflux Disease: Diagnosis and Management

Magnesium Hydroxide [Mg(OH)2] – Magnesium hydroxide is best known as milk of magnesia. Like magnesium citrate or magnesium sulfate, it is an effective laxative. Were it not for its tendency to cause diarrhea, magnesium hydroxide would be the most ideal antacid. To counter the diarrhea effect, most manufacturers add aluminum hydroxide, which is constipating.

The samples are for laboratory use only, have been stored with non-food-grade laboratory chemicals and are not meant for human consumption. Hydrochloric acid solution is toxic by ingestion and inhalation and is corrosive to skin and eyes.

The need for antacids can be minimized by eating a healthy diet, avoiding stress, and limiting your consumption of coffee, fatty foods, and chocolate. Alka-Seltzer is a popular antacid and pain relief medicine, containing aspirin, citric acid and sodium bicarbonate (baking soda). When the tablet is dropped into water, the bicarbonate and the citric acid dissolve, producing the familiar “fizz” from the chemical release of carbon dioxide. However, the American Medical Association does not recommend using sodium bicarbonate as an antacid because the sodium ions and bicarbonate ions are absorbed by the blood, causing alkalosis in extreme cases. Furthermore, individuals with high blood pressure or a heart condition are advised to avoid excess sodium and thus may choose to use an antacid without sodium bicarbonate.

They could be very economical in comparison to other natural antacids. Together with all what has been mentioned before, it is very well known that clays have a variety of pharmaceutical applications. Those medical properties, in combination with an antacid effect, make this material a good multipurpose medical drug.

During digestion, the stomach lining produces HCl. The average adult produces two to three liters of HCl every day to aid in digestion, with a normal stomach pH ranging from 0.9 to 2.0.

This decreases the amount of stomach acid that splashes back into the esophagus. Acid blockers in prescription strength block stomach acid, and treat stomach or duodenal ulcers, erosive esophagitis, and GERD by reducing the production of stomach acid. They may also be used for other conditions as determined by your doctor. Over-the-counter (OTC) antacids and acid blockers are the most commonly used medicines for treating heartburn.

The principal approach to treatment of GERD is to reduce gastric acidity. There are powerful drugs used to reduce the secretion of acid, which include the histamine2 (H2) receptor antagonists, and the proton pump inhibitors, or PPIs.

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