From Studio to Situations: Contemporary Art and the Question of Context. Installation Art in the New Millennium: The Empire of the Senses. At a Distance: Precursors to Art and Activism on the Internet. The San Francisco Tape Music Center: 1960s Counterculture and the Avant-Garde. The 25-Year Retrospective Concert of The Music of John Cage (album liner notes.)
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CD161(++) CD8(+) T cells represent a novel subset that is dominated in adult peripheral blood by mucosal-associated invariant T (MAIT) cells, as defined by the expression of a Vα7.2-Jα33 TCR, and IL-18Rα. We show that modified human MR1 tetramers loaded with the potent MAIT cell ligand, reduced 6-hydroxymethyl-8-d-ribityllumazine (rRL-6-CH2OH), specifically detect all human MAIT cells.
Perturbation of mucosal-associated invariant T cells and iNKT cells in HIV infection Impairment of IFN-g and IL-17A cytokine secretion by MAIT cells upon Escherichia coli stimulation is partially restored with ART, although TNF production and CD69 expression were not restored with therapy. This T–T cell-mediated signaling also induced IFNγ, TNF and granzyme B from MAIT cells, albeit at lower level than professional APC. Remarkably, we found that human T-cell subsets can also present riboflavin metabolites to MAIT cells in a MR1-restricted fashion. Activation of MAIT cells by high- vs low-stimulating bacteria also correlated with the level of riboflavin they secreted or after bacterial infection of macrophages.
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